Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Questionable
Based on 15 Reviews
5.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
7,500 mcg
833%
Top Medical Research Studies
9
We aimed to understand how retinoic acid (RA), a derivative of vitamin A, impacts hair loss, particularly in individuals suffering from androgenetic alopecia (AGA). By examining hair follicles from both the occipital and frontal areas of the scalp, we were able to conduct RNA sequencing to observe patterns relevant to HFSC (hair follicle stem cell) health.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
Read More
Most Useful Reviews
0
Warning on toxicity
35 people found this helpful
This is NOT a safe substitute for Accutane. While some report clear skin from this product, it is crucial to understand the risks. High doses of retinol can be toxic and, ironically, can cause severe hair loss. It's not worth risking permanent damage.
Read More
0
Severe hair loss
19 people found this helpful
DO NOT TAKE THIS UNLESS YOU WANT TO LOSE YOUR HAIR. This is the worst supplement I have ever taken. The label should read "MAY CAUSE SEVERE HAIR LOSS" or it should not be sold at all. At 33, I’ve had no thinning hair, and it’s not in my family. I thought this might help my skin but after starting it, I developed a one-inch balding spot on the left side of my head, and soon after, one on the right. I discovered that extra vitamin A can cause balding, and the dermatologist advised me to stop immediately. Now I just hope my hair grows back. I am furious that this is not labelled for high risk of causing baldness.
Read More
0
Caution on overdosing
18 people found this helpful
THIS IS A TOXIC DOSE OF VITAMIN A!!! I have taken this daily since January. My hair has started thinning, which is concerning as I have thick hair and no family history of hair loss. The dose is excessive and can lead to hair loss. It's vital to know your proper intake levels to avoid this reversible cause of hair loss.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We aimed to understand how retinoic acid (RA), a derivative of vitamin A, impacts hair loss, particularly in individuals suffering from androgenetic alopecia (AGA). By examining hair follicles from both the occipital and frontal areas of the scalp, we were able to conduct RNA sequencing to observe patterns relevant to HFSC (hair follicle stem cell) health.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
Read More
User Reviews
USERS' SCORE
Questionable
Based on 15 Reviews
5.4
- All Reviews
- Positive Reviews
- Negative Reviews
0
Warning on toxicity
35 people found this helpful
This is NOT a safe substitute for Accutane. While some report clear skin from this product, it is crucial to understand the risks. High doses of retinol can be toxic and, ironically, can cause severe hair loss. It's not worth risking permanent damage.
Read More
0
Severe hair loss
19 people found this helpful
DO NOT TAKE THIS UNLESS YOU WANT TO LOSE YOUR HAIR. This is the worst supplement I have ever taken. The label should read "MAY CAUSE SEVERE HAIR LOSS" or it should not be sold at all. At 33, I’ve had no thinning hair, and it’s not in my family. I thought this might help my skin but after starting it, I developed a one-inch balding spot on the left side of my head, and soon after, one on the right. I discovered that extra vitamin A can cause balding, and the dermatologist advised me to stop immediately. Now I just hope my hair grows back. I am furious that this is not labelled for high risk of causing baldness.
Read More
0
Caution on overdosing
18 people found this helpful
THIS IS A TOXIC DOSE OF VITAMIN A!!! I have taken this daily since January. My hair has started thinning, which is concerning as I have thick hair and no family history of hair loss. The dose is excessive and can lead to hair loss. It's vital to know your proper intake levels to avoid this reversible cause of hair loss.
Read More
9
Healthy hair improvement
I've struggled with hair loss for years, but after taking this supplement alongside Biotin, Zinc, Potassium, vitamins E, D, C, and some B vitamins, my hair no longer falls out significantly and is much healthier. I have no split ends even without trimming for 6 months.
Read More
9
Stopped hair loss
After taking vitamin E and vitamin A for 10 days, my hair stopped falling out! I was very surprised by the result! A lack of vitamin A can manifest as dry skin, brittleness, and hair loss, along with white stripes on the nails.
Read More
Frequently Asked Questions
6
Promotes improvement
Great value! I used this for hair loss and folliculitis, and I noticed an improvement within a few weeks.
6
Reduced hair loss
For over 6 months, I've taken it and noticed improved eyesight with a small daily dose. The quality is good, and it’s easy to swallow. It also helped reduce hair loss.
9
Stopped hair loss
After taking vitamin E and vitamin A for 10 days, my hair stopped falling out! I was very surprised by the result! A lack of vitamin A can manifest as dry skin, brittleness, and hair loss, along with white stripes on the nails.
9
Healthy hair improvement
I've struggled with hair loss for years, but after taking this supplement alongside Biotin, Zinc, Potassium, vitamins E, D, C, and some B vitamins, my hair no longer falls out significantly and is much healthier. I have no split ends even without trimming for 6 months.
7.5
Nails and skin improved
I purchased these vitamins due to excessive hair loss, and I'm very pleased, as they also benefit my nails and skin. Undoubtedly, a highly comprehensive product.
7.5
Significant results
Excellent vitamins! After taking them for two years, my hair loss has significantly decreased, and my skin condition has improved. These vitamins truly work, and I recommend them.
6
Hair loss reduction
I take one pill at a time alongside MSM. Although warned about fat-soluble vitamins, I've experienced no issues. I aimed to increase collagen in my body, and I’ve continued taking it. My hair loss has decreased significantly, and my nails are stronger.
7.5
Clear skin benefits
4 people found this helpful
The cosmetologist prescribed vitamin A to improve my skin and combat hair loss. The benefits include clear skin, but this vitamin has many contraindications, so do not self-prescribe. It feels wonderful to see beautiful, clear skin!
9
We aimed to understand how retinoic acid (RA), a derivative of vitamin A, impacts hair loss, particularly in individuals suffering from androgenetic alopecia (AGA). By examining hair follicles from both the occipital and frontal areas of the scalp, we were able to conduct RNA sequencing to observe patterns relevant to HFSC (hair follicle stem cell) health.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
References
- Wen L, Fan Z, Huang W, Miao Y, Zhang J, et al. Retinoic acid drives hair follicle stem cell activation via Wnt/β-catenin signalling in androgenetic alopecia. J Eur Acad Dermatol Venereol. 2025;39:189. doi:10.1111/jdv.20000
